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FIRB-HRBC
Breast cancer is the leading cause of cancer morbidity in women, accounting for close to one fourth of all new cancer cases in the female population; one out of ten women is likely to develop breast cancer in her lifetime. The project will focus on the definition of a set of genes involved in human breast cancer that will serve as a basis for the design of a common microarray platform. The platform will be used by all partners for carrying out gene expression profiling experiments. A common database will be implemented where all data gathered on each individual gene under study will be stored and made accessible to all participant laboratories. In addition, a separate database will link patient and gene expression data.
- to provide exploitable information on the molecular basis of estrogen actions in Breast Cancer cells and on the functions of the products encoded by the newly identified hormone-responsive genes and their biological roles in BC cells
- to investigate the possibility that some of such genes might represent novel and informative molecular markers for molecular and immuno phenotypic characterization of breast tumors
- the clinical partners will carry out morphological, cytogenetic, genomic and proteomic analysis of breast cancer biopsies, focusing mainly on the genes identified in the hormone-responsive cell lines and other model systems as transgenic mice
- to search for correlations between expression or mutations of these genes and the clinical outcome of the disease
Alessandro Weisz, Department of General Pathology, Second University of Naples
Saverio Minucci, Department of Experimental Oncology, IEO, MILANO
Giovanni Colonna, CRISCEB, Second University of Naples Paolo Romano, IST, Genova
Angelo Facchiano, CNR, Avellino
Elda Rossi, CINECA, Bologna
Massimo Negrini, University of Ferrara
Michele De Bortoli, Department of Oncology - IRCC, University of Turin
Adriana Caterina Maggi, University of Milan
Antonio Malorni, CESMA-ProBio, CNR, Avellino